Property Plant and Equipment (Detail) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	$ 1,141,362	$ 982,810
Less: Accumulated depreciation	(342,594)	(278,603)
Total property, plant and equipment, net	798,768	704,207
Building and Improvements
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	510,805	442,100
Manufacturing and Laboratory Equipment
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	242,899	145,313
Computer Hardware and Software
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	129,506	113,442
Leasehold Improvements
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	44,184	44,247
Furniture and Equipment
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	27,229	22,817
Land Improvements
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	4,881	4,881
Land
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	55,412	45,727
Construction-in-Progress
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	$ 126,446	$ 164,283