INCOME TAXES (Tables)

12 Months Ended

Dec. 31, 2016

Schedule of Provision for (Benefit from) Income Taxes Based on Loss Before Income Taxes

The provision for (benefit from) income taxes is based on loss before income taxes as follows:

	Years Ended December 31,
	2016			2015			2014
U.S. Source	$	10,696		$	182,215		$	49,411
Non-U.S. Source		(841,746	)		(336,939	)		(174,279	)
Loss before income taxes	$	(831,050	)	$	(154,724	)	$	(124,868	)

Schedule of Components of Provision for (Benefit From) Income Taxes

The U.S. and foreign components of the provision for (benefit from) income taxes are as follows:

	Years Ended December 31,
	2016			2015			2014
Provision for current income tax expense:
Federal	$	22,239		$	84,743		$	28,093
State and local		1,418			5,323			3,011
Foreign		3,557			3,836			3,614
		27,214			93,902			34,718
Provision for (benefit from) deferred income tax expense:
Federal		(78,428	)		(17,741	)		(20,367	)
State and local		(6,012	)		(8,770	)		(4,982	)
Foreign		(143,614	)		(50,316	)		(268	)
		(228,054	)		(76,827	)		(25,617	)
Provision for (benefit from) income taxes	$	(200,840	)	$	17,075		$	9,101

Schedule of Reconciliation of Statutory Federal Income Tax Rate to Company's Effective Income Tax Rate

The following is a reconciliation of the statutory federal income tax rate to the Company’s effective income tax rate expressed as a percentage of loss before income taxes:

	Years Ended December 31,
	2016			2015			2014
Federal statutory income tax rate		35.0	%		35.0	%		35.0	%
State and local taxes		0.4	%		(2.2	)%		(1.6	)%
Orphan Drug & General Business Credit		7.5	%		34.8	%		29.3	%
Stock compensation expense		4.6	%		(2.8	)%		(2.4	)%
Changes in the fair value of contingent acquisition consideration payable		0.9	%		0.2	%		(3.6	)%
Subpart F income		—	%		(8.4	)%		(9.2	)%
Foreign tax rate differential		(18.6	)%		(46.2	)%		(51.5	)%
Section 162(m) limitation		(5.4	)%		(1.3	)%		(1.7	)%
Other		0.3	%		(1.6	)%		(1.9	)%
Valuation allowance/deferred benefit		(0.5	)%		(18.5	)%		0.3	%
Effective income tax rate		24.2	%		(11.0	)%		(7.3	)%

Schedule of Components of Net Deferred Tax Assets

The significant components of the Company’s net deferred tax assets are as follows:

	December 31,
	2016			2015
Net deferred tax assets:
Net operating loss carryforwards	$	49,787		$	44,942
Tax credit carryforwards		352,535			143,987
Accrued expenses, reserves, and prepaids		77,904			79,029
Intangible assets		26,751			16,177
Stock-based compensation		47,713			49,322
Inventory		15,581			18,942
Impairment		5,017			5,005
Other		1,415			1,155
Valuation allowance		(73,037	)		(67,708	)
Total deferred tax assets		503,666			290,851

Joint venture basis difference		(1,714	)		(1,888	)
Acquired intangibles		(8,773	)		(162,689	)
Convertible notes discount		(24,394	)		(32,162	)
Property, plant and equipment		(22,103	)		(13,192	)
Unrealized (gains) losses		104			(4,256	)
Total deferred tax liabilities		(56,880	)		(214,187	)
Net deferred tax assets	$	446,786		$	76,664

Schedule of Reconciliation of Unrecognized Tax Benefits

A reconciliation of the beginning and ending amount of unrecognized tax benefits for the years ended December 31, 2016 is as follows:

	December 31,
	2016		2015
Balance at beginning of period	$	86,731	$	71,663
Additions based on tax positions related to the current year		15,982		13,614
Additions for tax positions of prior years	497			1,454
Balance at end of period	$	103,210	$	86,731