CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (171,799)	$ (133,969)	$ (176,353)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization expense	47,187	45,871	36,014
Non-cash interest expense	28,493	27,225	5,875
Accretion of discount on investments	2,177	7,211	5,899
Stock-based compensation expense	111,525	86,410	64,376
Gain on sale of intangible asset	(369,498)	(67,500)
Gain on termination of leases		(10,092)
Gain on sale of equity investment	(3,022)
Impairment of assets	211,502		939
Deferred income taxes	(76,827)	(25,617)	(8,905)
Excess tax benefit from stock option exercises	(2,190)	(1,491)	(733)
Unrealized foreign exchange gain on forward contracts	(19,575)	(832)	(658)
Non-cash changes in the fair value of contingent acquisition consideration payable	(28,457)	11,567	10,197
Debt conversion expense	163	674	12,965
Other	2,300	4,514	1,149
Changes in operating assets and liabilities:
Accounts receivable, net	(16,367)	(25,951)	(8,740)
Inventory	(50,989)	(22,339)	(21,102)
Other current assets	25,800	(2,211)	(12,073)
Other assets	(3,157)	(6,516)	3,952
Accounts payable and accrued liabilities	90,298	38,040	20,304
Other long-term liabilities	747	3,093	9,559
Net cash used in operating activities	(221,689)	(71,913)	(57,335)
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of property, plant and equipment	(227,653)	(117,062)	(65,193)
Funds held in escrow for the purchase of real property			(116,500)
Deposit on purchase of PKU rights	(371,756)
Maturities and sales of investments	424,713	808,313	288,643
Purchase of available-for-sale investments	(873,184)	(507,036)	(395,042)
Proceeds from sale of intangible asset	410,000	67,500
Business acquisitions, net of cash acquired	(538,392)		(9,875)
Investment in convertible promissory note	(3,326)	(52,288)
Other		(3,100)	(885)
Net cash provided by (used in) investing activities	(1,179,598)	196,327	(298,852)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from exercises of stock options and the ESPP	63,045	79,904	72,579
Taxes paid related to net share settlement of equity awards	(22,989)	(7,768)	(6,397)
Proceeds from convertible senior note offering, net			726,202
Purchase of capped call share options			(29,813)
Proceeds from public offering of common stock, net	888,257	117,464
Excess tax benefit from stock option exercises	2,190	1,491	733
Payments for debt conversion	(163)	(674)	(12,965)
Payment of contingent acquisition consideration payable		(4,691)	(3,061)
Other	(2,427)	(37)	(607)
Net cash provided by financing activities	927,913	185,689	746,671
Effect of exchange rate changes on cash	(5,072)	(3,398)	(2,230)
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS	(478,446)	306,705	388,254
Cash and cash equivalents:
Beginning of period	875,486	568,781	180,527
End of period	397,040	875,486	568,781
SUPPLEMENTAL CASH FLOW DISCLOSURES:
Cash paid for interest, net of interest capitalized into fixed assets	9,307	9,324	2,159
Cash paid for income taxes	16,084	34,986	14,897
Stock-based compensation capitalized into inventory	11,140	8,166	6,121
Depreciation capitalized into inventory	14,627	10,952	11,016
SUPPLEMENTAL CASH FLOW DISCLOSURES FROM INVESTING AND FINANCING ACTIVITIES:
Increase (decrease) in accounts payable and accrued liabilities related to fixed assets	(4,651)	16,766	5,001
Conversion of convertible debt, net	$ 9,112	$ 21,324	$ 283,319