Property Plant and Equipment (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	$ 982,810	$ 752,405
Less: Accumulated depreciation	(278,603)	(228,889)
Total property, plant and equipment, net	704,207	523,516
Building and Improvements
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	442,100	335,991
Manufacturing and Laboratory Equipment
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	145,313	124,564
Computer Hardware and Software
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	113,442	97,032
Leasehold Improvements
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	44,247	39,297
Furniture and Equipment
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	22,817	13,717
Land Improvements
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	4,881	4,106
Land
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	45,727	29,358
Construction-in-Progress
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross	$ 164,283	$ 108,340