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Consolidated Net Product Revenue Concentrations Attributed to Largest Customers (Detail) - Customer Concentration Risk - Net Product Revenue
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Concentration Risk [Line Items]      
Concentration risk, percentage 49.00% 52.00% 51.00%
Customer A      
Concentration Risk [Line Items]      
Concentration risk, percentage 15.00% 15.00% 15.00%
Customer B      
Concentration Risk [Line Items]      
Concentration risk, percentage [1] 11.00% 14.00% 16.00%
Customer C      
Concentration Risk [Line Items]      
Concentration risk, percentage 10.00% 12.00% 9.00%
Customer D      
Concentration Risk [Line Items]      
Concentration risk, percentage 13.00% 11.00% 11.00%
[1] Genzyme is the Company’s sole customer for Aldurazyme and is responsible for marketing and selling Aldurazyme to third-parties. Net product revenues from Genzyme consists of royalties on worldwide net Aldurazyme sales and incremental product transfer revenue.