Amounts Reclassified out of Accumulated Other Comprehensive Income (Loss) (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Reclassification Adjustment Out Of Accumulated Other Comprehensive Income [Line Items]
Net product revenues	$ 884,522	$ 738,416	$ 538,360
Selling, general and administrative	402,271	302,156	235,356
Other income (expense)	(9,299)	279	982
Provision for (benefit from) income taxes	17,075	9,101	(150)
NET LOSS	(171,799)	(133,969)	$ (176,353)
Amount Reclassified from AOCI Gain (Loss) | Other-than-temporary impairment on available-for-sale securities
Reclassification Adjustment Out Of Accumulated Other Comprehensive Income [Line Items]
Other income (expense)	(1,160)
Amount Reclassified from AOCI Gain (Loss) | Gain on sale of available-for-sale investment
Reclassification Adjustment Out Of Accumulated Other Comprehensive Income [Line Items]
Other income (expense)	3,033
Amount Reclassified from AOCI Gain (Loss) | Gain (loss) on cash flow hedges: | Forward Foreign Currency Exchange Contracts
Reclassification Adjustment Out Of Accumulated Other Comprehensive Income [Line Items]
Net product revenues	17,715	1,008
Selling, general and administrative	1,889
Provision for (benefit from) income taxes	681	365
NET LOSS	$ 20,796	$ 643