Condensed Consolidated Statements Of Cash Flows (USD $) In Thousands	9 Months Ended
	Sep. 30, 2011		Sep. 30, 2010
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income (loss)	$ (27,101)		$ 218,008
Adjustments to reconcile net income (loss) to net cash provided by operating activities:
Depreciation and amortization	26,466		19,806
Amortization of discount on investments	3,055		3,506
Equity in the loss of BioMarin/Genzyme LLC	1,817
Stock-based compensation	32,721		28,527
Net gain from sale of investments	0		(927)
Deferred income taxes	6,844		(223,065)
Excess tax benefit from stock option exercises	(109)		(32)
Unrealized foreign exchange (loss) gain on forward contracts	5,699		(3,669)
Changes in the fair value of contingent acquisition consideration payable	(2,390)		4,596
Debt conversion expense	1,896		0
Changes in operating assets and liabilities:
Accounts receivable, net	(20,481)		(5,194)
Inventory	(5,930)		(13,079)
Other current assets	(6,147)		646
Other assets	110		(2,148)
Accounts payable and accrued liabilities	1,459		4,318
Other long-term liabilities	1,019		1,040
Net cash provided by operating activities	18,928		34,528
CASH FLOWS FROM INVESTING ACTIVITIES
Purchases of property, plant and equipment	(64,539)		(38,720)
Maturities and sales of investments	227,094		135,739
Purchase of available-for-sale investments	(215,298)		(148,886)
Business acquisitions, net of cash acquired	0		(32,950)
Investments in BioMarin/Genzyme LLC	(1,903)		(2,915)
Net cash used in investing activities	(54,646)		(87,732)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from Employee Stock Purchase Plan (ESPP) and exercise of stock options	23,436		19,888
Excess tax benefit from stock option exercises	109		32
Net payment on debt conversion	(2,234)		0
Payment of contingent acquisition consideration payable	(1,894)		(6,230)
Repayment of capital lease obligations	(524)		(118)
Net cash provided by financing activities	18,893		13,572
NET DECREASE IN CASH AND CASH EQUIVALENTS	(16,825)		(39,632)
Cash and cash equivalents:
Beginning of period	88,079	[1]	167,171
End of period	71,254		127,539
SUPPLEMENTAL CASH FLOW DISCLOSURES:
Cash paid for interest, net of interest capitalized into fixed assets	4,019		6,675
Cash paid for income taxes	3,386		2,904
Stock-based compensation capitalized into inventory	3,978		3,705
Depreciation capitalized into inventory	4,067		3,179
SUPPLEMENTAL CASH FLOW DISCLOSURES FROM INVESTING AND FINANCING ACTIVITIES:
Decrease in accrued liabilities related to fixed assets	(2,373)		(7,606)
Equipment acquired through capital leases	$ 190		$ 0

[1] December 31, 2010 balances were derived from the audited consolidated financial statements.