Condensed Consolidated Statements Of Cash Flows (USD $) In Thousands	6 Months Ended
	Jun. 30, 2011		Jun. 30, 2010
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income (loss)	$ (9,448)		$ 674
Adjustments to reconcile net income (loss) to net cash provided by operating activities:
Depreciation and amortization	17,116		11,987
Amortization of discount on investments	2,053		2,501
Equity in the loss of BioMarin/Genzyme LLC	1,209		1,555
Stock-based compensation	20,937		18,233
Net gain from sale of investments	0		(927)
Deferred income taxes	6,993		0
Excess tax benefit from stock option exercises	(28)		(13)
Unrealized foreign exchange (gain) loss on forward contracts	2,117		(1,475)
Changes in the fair value of contingent acquisition consideration payable	(4,624)		1,453
Changes in operating assets and liabilities:
Accounts receivable, net	(20,030)		(4,142)
Inventory	(2,601)		(5,116)
Other current assets	(3,258)		1,287
Other assets	1,749		(2,646)
Accounts payable and accrued liabilities	(2,687)		1,753
Other long-term liabilities	569		347
Net cash provided by operating activities	10,067		25,471
CASH FLOWS FROM INVESTING ACTIVITIES
Purchases of property, plant and equipment	(8,151)		(29,348)
Maturities and sales of investments	145,639		50,682
Purchase of available-for-sale investments	(132,565)		(89,472)
Business acquisitions, net of cash acquired	0		(14,124)
Investments in BioMarin/Genzyme LLC	(1,248)		(1,465)
Net cash provided by (used in) investing activities	3,675		(83,727)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from Employee Stock Purchase Plan (ESPP) and exercise of stock options	11,578		13,166
Excess tax benefit from stock option exercises	28		13
Payment of contingent acquisition consideration payable	0		(6,230)
Repayment of capital lease obligations	(471)		(85)
Net cash provided by financing activities	11,135		6,864
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS	24,877		(51,392)
Cash and cash equivalents:
Beginning of period	88,079	[1]	167,171
End of period	112,956		115,779
SUPPLEMENTAL CASH FLOW DISCLOSURES:
Cash paid for interest, net of interest capitalized into fixed assets	3,683		4,524
Cash paid for income taxes	2,298		1,183
Stock-based compensation capitalized into inventory	2,479		2,324
Depreciation capitalized into inventory	2,002		1,679
SUPPLEMENTAL CASH FLOW DISCLOSURES FROM INVESTING AND FINANCING ACTIVITIES:
Changes in accrued liabilities related to fixed assets	(1,896)		5,790
Equipment acquired through capital leases	$ 366		$ 0

[1] December 31, 2010 balances were derived from the audited consolidated financial statements.