X0306 4 2015-11-16 0 0001048477 BIOMARIN PHARMACEUTICAL INC BMRN 0001240122 GREY MICHAEL G C/O BIOMARIN PHARMACEUTICAL INC. 105 DIGITAL DRIVE NOVATO CA 94949 1 0 0 0 Common Stock 2015-11-16 2015-11-16 4 M 0 7500 38.59 A 33750 D Common Stock 2015-11-16 2015-11-16 4 S 0 7500 104.2738 D 26250 D Stock Option (right to buy) Common Stock 38.59 2015-11-16 2015-11-16 4 M 0 7500 0 D 2008-11-22 2018-05-21 Common Stock 7500 7500 D Trade made pursuant to a 10b5-1 plan executed on August 14, 2015. The price in column 4 is a weighted average price. The price actually received ranged from $102.98 to $106.81. The reporting person shall provide to the issuer, and security holder of the issuer, or the SEC staff upon request, information regarding the number of shares sold at each price within the range Original option grant vests 6/48ths on November 22, 2008, and 1/48th on the 22nd day of every month thereafter. Reflects the number of stocks options that remain outstanding from this specific stock option grant following the reported transaction. /s/ Laura Randall Woodhead, Attorney-in-Fact 2015-11-18