X0306 4 2012-12-31 0 0001048477 BIOMARIN PHARMACEUTICAL INC BMRN 0001221590 BIENAIME JEAN JACQUES C/O BIOMARIN PHARMACEUTICAL INC. 105 DIGITAL DRIVE NOVATO CA 94949 1 1 0 0 Chief Executive Officer Common Stock 2012-12-31 2012-12-31 4 M 0 5000 12.99 D 172691 D Common Stock 2012-12-31 2012-12-31 4 S 0 5000 48.6232 D 167691 D Stock Option (right to buy) Common Stock 12.99 2012-12-31 2012-12-31 4 M 0 5000 0 D 2006-11-11 2016-05-10 Common Stock 5000 2202764 D Transaction made pursuant to a Rule 10b5-1 Trading plan executed on August 10, 2012. The price in Column 4 is a weighted average price. The prices actually received ranged from $47.72 to $49.07. The reporting person will provide to the issue, any security holder of the issuer, or SEC staff, upon request, information regarding the number of shares sold at each price within the range. Original option grant vests 6/48th on November 11, 2006 and 1/48th on the 11th day of every month thereafter. /s/ Laura Randall Woodhead, Attorney-in-Fact 2013-01-03