CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
CASH FLOWS FROM OPERATING ACTIVITIES:
NET INCOME	$ 348,901	$ 426,859	$ 167,645
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization	79,557	96,426	104,386
Non-cash interest expense	2,622	3,359	4,188
Accretion of discount on investments	(4,801)	(8,345)	(9,228)
Stock-based compensation	181,409	201,571	207,099
Gain on sale of nonfinancial assets	0	(10,000)	0
Impairment of assets	125,012	19,889	38,608
ROCTAVIAN inventory write-off	119,208	0	0
Deferred income taxes	48,738	56,096	(44,981)
Unrealized foreign exchange gain	4,459	(16,753)	28,446
Acquired in-process research & development expense	220,963	0	0
Other	(4,414)	20,135	(365)
Changes in operating assets and liabilities:
Accounts receivable, net	(228,054)	(57,909)	(190,435)
Inventory	(116,929)	(63,530)	(157,058)
Other current assets	8,891	(3,778)	(50,335)
Other assets	(38,573)	(73,700)	(31,149)
Accounts payable and accrued liabilities	66,136	(32,240)	68,853
Other long-term liabilities	14,869	14,761	23,585
Net cash provided by operating activities	827,994	572,841	159,259
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of property, plant and equipment	(103,038)	(85,424)	(96,691)
Maturities and sales of investments	337,801	633,018	864,863
Purchases of investments	(355,875)	(410,250)	(868,496)
Proceeds from sale of nonfinancial assets	0	10,000	0
Purchase of intangible assets	(7,937)	(11,994)	(10,920)
Acquisition, net of cash acquired	(285,193)	0	0
Other	0	1,141	0
Net cash provided by (used in) investing activities	(414,242)	136,491	(111,244)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from exercises of awards under equity incentive plans	14,460	49,277	69,353
Taxes paid related to net share settlement of equity awards	(55,965)	(77,560)	(76,319)
Repayments of convertible debt	0	(494,987)	0
Other	(889)	(3,177)	(11,761)
Net cash used in financing activities	(42,394)	(526,447)	(18,727)
Effect of exchange rate changes on cash	(2,521)	4,830	1,308
NET INCREASE IN CASH AND CASH EQUIVALENTS	368,837	187,715	30,596
Cash and cash equivalents:
Beginning of period	942,842	755,127	724,531
End of period	1,311,679	942,842	755,127
SUPPLEMENTAL CASH FLOW DISCLOSURES:
Cash paid for interest	7,245	10,361	10,303
Cash paid for income taxes	96,205	57,269	73,312
SUPPLEMENTAL CASH FLOW DISCLOSURES FOR NON-CASH INVESTING AND FINANCING ACTIVITIES:
Accounts payable and accrued liabilities related to fixed assets	3,780	3,751	10,280
Accounts payable and accrued liabilities related to intangible assets	$ 1,247	$ 6,327	$ 8,000