CONSOLIDATED STATEMENTS OF INCOME - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
REVENUES:
Total revenues	$ 3,221,253	$ 2,853,915	$ 2,419,226
OPERATING EXPENSES:
Cost of sales	717,442	580,235	532,062
Research and development	921,930	747,184	746,773
Selling, general and administrative	1,153,017	1,009,025	892,406
Intangible asset amortization	19,386	43,257	62,211
Gain on sale of nonfinancial assets	0	(10,000)	0
Total operating expenses	2,811,775	2,369,701	2,233,452
INCOME FROM OPERATIONS	409,478	484,214	185,774
Interest income	74,904	74,883	58,339
Interest expense	(10,899)	(12,666)	(17,335)
Other income (expense), net	8,997	(4,668)	(38,215)
INCOME BEFORE INCOME TAXES	482,480	541,763	188,563
Provision for income taxes	133,579	114,904	20,918
NET INCOME	$ 348,901	$ 426,859	$ 167,645
EARNINGS PER SHARE, BASIC (in dollars per share)	$ 1.82	$ 2.25	$ 0.89
EARNINGS PER SHARE, DILUTED (in dollars per share)	$ 1.80	$ 2.21	$ 0.87
Weighted-average common shares outstanding, basic (in shares)	191,787	190,027	187,834
Weighted average common shares outstanding, diluted (in shares)	197,394	196,708	191,595
Net product revenues
REVENUES:
Total revenues	$ 3,167,759	$ 2,809,445	$ 2,372,538
Royalty and other revenues
REVENUES:
Total revenues	$ 53,494	$ 44,470	$ 46,688