CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2025	Sep. 30, 2024
REVENUES:
Total revenues	$ 776,133	$ 745,740	$ 2,346,688	$ 2,106,602
OPERATING EXPENSES:
Cost of sales	140,085	188,457	441,733	444,096
Research and development	409,478	184,901	729,517	573,675
Selling, general and administrative	268,415	253,480	706,810	742,418
Intangible asset amortization	4,847	5,009	14,540	33,606
Gain on sale of nonfinancial assets	0	0	0	(10,000)
Total operating expenses	822,825	631,847	1,892,600	1,783,795
INCOME (LOSS) FROM OPERATIONS	(46,692)	113,893	454,088	322,807
Interest income	17,854	18,053	55,694	57,203
Interest expense	(2,579)	(2,968)	(8,121)	(10,089)
Other income, net	5,093	5,463	7,972	2,203
INCOME (LOSS) BEFORE INCOME TAXES	(26,324)	134,441	509,633	372,124
Provision for income taxes	4,420	28,361	114,159	70,208
NET INCOME (LOSS)	$ (30,744)	$ 106,080	$ 395,474	$ 301,916
EARNINGS (LOSS) PER SHARE, BASIC (in dollars per share)	$ (0.16)	$ 0.56	$ 2.06	$ 1.59
EARNINGS (LOSS) PER SHARE, DILUTED (in dollars per share)	$ (0.16)	$ 0.55	$ 2.04	$ 1.56
Weighted average common shares outstanding, basic (in shares)	192,032	190,429	191,639	189,806
Weighted average common shares outstanding, diluted (in shares)	192,032	197,147	196,893	196,683
COMPREHENSIVE INCOME (LOSS)	$ (20,116)	$ 83,931	$ 299,884	$ 335,354
Net product revenues
REVENUES:
Total revenues	760,812	733,867	2,308,438	2,073,811
Royalty and other revenues
REVENUES:
Total revenues	$ 15,321	$ 11,873	$ 38,250	$ 32,791