CONSOLIDATED STATEMENTS OF INCOME - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
REVENUES:
Total revenues	$ 2,853,915	$ 2,419,226	$ 2,096,039
OPERATING EXPENSES:
Cost of sales	580,235	532,062	503,023
Research and development	747,184	746,773	649,606
Selling, general and administrative	1,009,025	892,406	823,243
Intangible asset amortization	43,257	62,211	67,193
Gain on sale of nonfinancial assets	(10,000)	0	(108,000)
Total operating expenses	2,369,701	2,233,452	1,935,065
INCOME FROM OPERATIONS	484,214	185,774	160,974
Interest income	74,883	58,339	18,034
Interest expense	(12,666)	(17,335)	(15,970)
Other expense, net	(4,668)	(38,215)	(13,462)
INCOME BEFORE INCOME TAXES	541,763	188,563	149,576
Provision for income taxes	114,904	20,918	8,015
NET INCOME	$ 426,859	$ 167,645	$ 141,561
EARNINGS PER SHARE, BASIC (in dollars per share)	$ 2.25	$ 0.89	$ 0.76
EARNINGS PER SHARE, DILUTED (in dollars per share)	$ 2.21	$ 0.87	$ 0.75
Weighted-average common shares outstanding, basic (in shares)	190,027	187,834	185,266
Weighted average common shares outstanding, diluted (in shares)	196,708	191,595	188,963
Net product revenues
REVENUES:
Total revenues	$ 2,809,445	$ 2,372,538	$ 2,042,025
Royalty and other revenues
REVENUES:
Total revenues	$ 44,470	$ 46,688	$ 54,014