CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
REVENUES:
Total revenues	$ 2,419,226	$ 2,096,039	$ 1,846,275
OPERATING EXPENSES:
Cost of sales	514,854	483,669	470,515
Research and development	746,773	649,606	628,793
Selling, general and administrative	937,291	854,009	759,375
Intangible asset amortization and contingent consideration	62,211	67,193	69,933
Gain on sale of nonfinancial assets, net	0	(108,000)	0
Total operating expenses	2,261,129	1,946,477	1,928,616
INCOME (LOSS) FROM OPERATIONS	158,097	149,562	(82,341)
Interest income	58,339	18,034	10,482
Interest expense	(17,335)	(15,970)	(15,337)
Other income (expense), net	(10,538)	(2,050)	11,846
INCOME (LOSS) BEFORE INCOME TAXES	188,563	149,576	(75,350)
Provision for (benefit from) income taxes	20,918	8,015	(11,270)
NET INCOME (LOSS)	$ 167,645	$ 141,561	$ (64,080)
EARNINGS (LOSS) PER SHARE, BASIC (in dollars per share)	$ 0.89	$ 0.76	$ (0.35)
EARNINGS (LOSS) PER SHARE, DILUTED (in dollars per share)	$ 0.87	$ 0.75	$ (0.35)
Weighted-average common shares outstanding, basic (in shares)	187,834	185,266	182,852
Weighted average common shares outstanding, diluted (in shares)	191,595	188,963	182,852
Net product revenues
REVENUES:
Total revenues	$ 2,372,538	$ 2,042,025	$ 1,783,498
Royalty and other revenues
REVENUES:
Total revenues	$ 46,688	$ 54,014	$ 62,777