REVENUE, CREDIT CONCENTRATIONS AND GEOGRAPHIC INFORMATION - Schedule of Net Product Revenues by Product (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022
Revenue from External Customer [Line Items]
Revenue	$ 581,329	$ 505,344	$ 1,773,019	$ 1,558,501
Product
Revenue from External Customer [Line Items]
Revenue	568,266	493,348	1,739,390	1,516,533
Total enzyme product revenues
Revenue from External Customer [Line Items]
Revenue	401,524	388,021	1,270,375	1,240,235
VIMIZIM
Revenue from External Customer [Line Items]
Revenue	158,869	155,470	525,453	511,735
NAGLAZYME
Revenue from External Customer [Line Items]
Revenue	108,916	99,506	322,040	343,320
PALYNZIQ
Revenue from External Customer [Line Items]
Revenue	78,885	66,206	216,105	182,734
BRINEURA
Revenue from External Customer [Line Items]
Revenue	41,042	37,793	118,244	111,691
ALDURAZYME
Revenue from External Customer [Line Items]
Revenue	13,812	29,046	88,533	90,755
VOXZOGO
Revenue from External Customer [Line Items]
Revenue	122,973	48,289	324,146	102,321
KUVAN
Revenue from External Customer [Line Items]
Revenue	42,947	57,038	144,047	173,977
ROCTAVIAN
Revenue from External Customer [Line Items]
Revenue	822	0	822	0
Royalty and other revenues
Revenue from External Customer [Line Items]
Revenue	$ 13,063	$ 11,996	$ 33,629	$ 41,968