REVENUE, CREDIT CONCENTRATIONS AND GEOGRAPHIC INFORMATION (Tables)

9 Months Ended

Sep. 30, 2023

Concentration Risk And Geographic Information [Abstract]

Schedule of Net Product Revenues by Product

The following table disaggregates total Net Product Revenues by product.

	Three Months Ended September 30,				Nine Months Ended September 30,
	2023		2022		2023		2022
Enzyme product revenues:
VIMIZIM	$	158,869	$	155,470	$	525,453	$	511,735
NAGLAZYME	108,916		99,506		322,040		343,320
PALYNZIQ	78,885		66,206		216,105		182,734
BRINEURA	41,042		37,793		118,244		111,691
ALDURAZYME	13,812		29,046		88,533		90,755
Total enzyme product revenues	401,524		388,021		1,270,375		1,240,235
VOXZOGO	122,973		48,289		324,146		102,321
KUVAN	42,947		57,038		144,047		173,977
ROCTAVIAN	822		—		822		—
Total net product revenues	568,266		493,348		1,739,390		1,516,533
Royalty and other revenues	13,063		11,996		33,629		41,968
Total revenues	$	581,329	$	505,344	$	1,773,019	$	1,558,501

Schedule of Total Net Product Revenues Based on Patient Location

The table below disaggregates total Net Product Revenues by geographic region, which is based on patient location for Company's commercial products sold directly by the Company, except for ALDURAZYME, which is marketed and sold exclusively by Sanofi worldwide.

	Three Months Ended September 30,				Nine Months Ended September 30,
	2023		2022		2023		2022
United States	$	194,745	$	176,552	$	553,184	$	497,205
Europe	168,784		162,583		512,910		480,645
Latin America	81,524		60,791		224,716		213,246
Rest of world	109,401		64,376		360,047		234,682
Total net product revenues marketed by the Company	$	554,454	$	464,302	$	1,650,857	$	1,425,778
ALDURAZYME net product revenues marketed by Sanofi	13,812		29,046		88,533		90,755
Total net product revenues	$	568,266	$	493,348	$	1,739,390	$	1,516,533

Schedule of Net Product Revenue Concentrations Attributed to Largest Customers

The following table illustrates the percentage of the Company’s total Net Product Revenues attributed to the Company’s largest customers for the periods presented. 

	Three Months Ended September 30,				Nine Months Ended September 30,
	2023		2022		2023		2022
Customer A	15	%	15	%	15	%	16	%
Customer B	13	%	14	%	12	%	12	%
Customer C	10	%	10	%	10	%	9	%
Total	38	%	39	%	37	%	37	%