REVENUE, CREDIT CONCENTRATIONS AND GEOGRAPHIC INFORMATION - Disaggregates of Net Product Revenues by Product (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Revenue from External Customer [Line Items]
Revenue	$ 595,275	$ 533,798	$ 1,191,690	$ 1,053,157
Product
Revenue from External Customer [Line Items]
Revenue	584,698	517,660	1,171,124	1,023,185
Total enzyme product revenues
Revenue from External Customer [Line Items]
Revenue	420,739	425,684	868,851	852,214
VIMIZIM
Revenue from External Customer [Line Items]
Revenue	177,392	173,206	366,584	356,265
NAGLAZYME
Revenue from External Customer [Line Items]
Revenue	90,103	115,783	213,124	243,814
PALYNZIQ
Revenue from External Customer [Line Items]
Revenue	74,868	61,643	137,220	116,528
ALDURAZYME
Revenue from External Customer [Line Items]
Revenue	40,318	37,327	74,721	61,709
BRINEURA
Revenue from External Customer [Line Items]
Revenue	38,058	37,725	77,202	73,898
VOXZOGO
Revenue from External Customer [Line Items]
Revenue	113,337	34,374	201,173	54,032
KUVAN
Revenue from External Customer [Line Items]
Revenue	50,622	57,602	101,100	116,939
Royalty and other revenues
Revenue from External Customer [Line Items]
Revenue	$ 10,577	$ 16,138	$ 20,566	$ 29,972