CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
REVENUES:
Total revenues	$ 595,275	$ 533,798	$ 1,191,690	$ 1,053,157
OPERATING EXPENSES:
Cost of sales	128,082	123,126	254,631	240,091
Research and development	177,363	158,190	349,209	319,026
Selling, general and administrative	215,336	196,835	438,339	391,454
Intangible asset amortization and contingent consideration	15,624	16,495	31,294	34,107
Gain on sale of nonfinancial assets, net	0	0	0	(108,000)
Total operating expenses	536,405	494,646	1,073,473	876,678
INCOME FROM OPERATIONS	58,870	39,152	118,217	176,479
Interest income	12,612	2,505	24,555	4,325
Interest expense	(3,755)	(3,859)	(7,458)	(7,665)
Other income (expense), net	3,083	(2,947)	(7,747)	(4,101)
INCOME BEFORE INCOME TAXES	70,810	34,851	127,567	169,038
Provision for income taxes	14,770	7,187	20,675	20,576
NET INCOME	$ 56,040	$ 27,664	$ 106,892	$ 148,462
Earnings per share, basic (in dollars per share)	$ 0.30	$ 0.15	$ 0.57	$ 0.80
Earnings per share, diluted (in dollars per share)	$ 0.29	$ 0.15	$ 0.56	$ 0.79
Weighted average common shares outstanding, basic (in shares)	187,948	185,254	187,311	184,710
Weighted average common shares outstanding, diluted (in shares)	194,998	187,448	194,756	191,096
COMPREHENSIVE INCOME	$ 48,145	$ 47,013	$ 92,142	$ 152,502
Net product revenues
REVENUES:
Total revenues	584,698	517,660	1,171,124	1,023,185
Royalty and other revenues
REVENUES:
Total revenues	$ 10,577	$ 16,138	$ 20,566	$ 29,972