REVENUE, CREDIT CONCENTRATIONS AND GEOGRAPHIC INFORMATION - Disaggregates of Net Product Revenues by Product (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Revenue from External Customer [Line Items]
Revenue	$ 596,415	$ 519,359
Product
Revenue from External Customer [Line Items]
Revenue	586,426	505,525
Total enzyme product revenues
Revenue from External Customer [Line Items]
Revenue	448,112	426,530
VIMIZIM
Revenue from External Customer [Line Items]
Revenue	189,192	183,059
NAGLAZYME
Revenue from External Customer [Line Items]
Revenue	123,021	128,031
PALYNZIQ
Revenue from External Customer [Line Items]
Revenue	62,352	54,885
BRINEURA
Revenue from External Customer [Line Items]
Revenue	39,144	36,173
ALDURAZYME
Revenue from External Customer [Line Items]
Revenue	34,403	24,382
Voxzogo
Revenue from External Customer [Line Items]
Revenue	87,836	19,658
KUVAN
Revenue from External Customer [Line Items]
Revenue	50,478	59,337
Royalty and other revenues
Revenue from External Customer [Line Items]
Revenue	$ 9,989	$ 13,834