CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income (loss)	$ 141,810	$ (6,182)
Adjustments to reconcile net income (loss) to net cash provided by operating activities:
Depreciation and amortization	77,416	82,053
Non-cash interest expense	3,089	3,114
Amortization of premium on investments	3,741	3,279
Stock-based compensation	149,574	153,372
Gain on sale of nonfinancial assets, net	(108,000)	0
Deferred income taxes	(743)	(12,020)
Unrealized foreign exchange gain	(16,075)	(1,347)
Non-cash changes in the fair value of contingent consideration	2,243	6,254
Other	(700)	(1,317)
Changes in operating assets and liabilities:
Accounts receivable, net	(53,752)	65,513
Inventory	(27,419)	(19,125)
Other current assets	(8,558)	27,029
Other assets	12,140	(407)
Accounts payable and other short-term liabilities	(2,398)	(7,129)
Other long-term liabilities	(3,252)	269
Net cash provided by operating activities	169,116	293,356
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of property, plant and equipment	(85,271)	(66,840)
Maturities and sales of investments	477,244	502,112
Purchases of investments	(457,382)	(737,144)
Proceeds from sale of nonfinancial assets	110,000	0
Purchase of intangible assets	(9,910)	(8,026)
Other	0	(994)
Net cash provided by (used in) investing activities	34,681	(310,892)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from exercises of awards under equity incentive plans	43,866	32,877
Taxes paid related to net share settlement of equity awards	(50,696)	(44,428)
Payment of contingent consideration	(21,054)	0
Principal repayments of financing leases	(1,635)	(2,492)
Other	0	(401)
Net cash used in financing activities	(29,519)	(14,444)
Effect of exchange rate changes on cash	(39)	(35)
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS	174,239	(32,015)
Cash and cash equivalents:
Beginning of period	587,276	649,158
End of period	761,515	617,143
SUPPLEMENTAL CASH FLOW DISCLOSURES:
Cash paid for income taxes	13,425	15,531
Cash paid for interest	6,575	6,673
SUPPLEMENTAL CASH FLOW DISCLOSURES FOR NON-CASH INVESTING AND FINANCING ACTIVITIES:
Decrease in accounts payable and accrued liabilities related to fixed assets	(5,240)	(7,690)
Increase (decrease) in accounts payable and accrued liabilities related to intangible assets	$ (224)	$ 9,386