CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
REVENUES:
Total revenues	$ 505,344	$ 408,742	$ 1,558,501	$ 1,396,465
OPERATING EXPENSES:
Cost of sales	116,288	103,537	356,379	350,765
Research and development	157,829	157,869	476,855	467,701
Selling, general and administrative	216,816	183,333	608,270	541,812
Intangible asset amortization and contingent consideration	16,828	17,222	50,935	52,648
Gain on sale of nonfinancial assets, net	0	0	(108,000)	0
Total operating expenses	507,761	461,961	1,384,439	1,412,926
INCOME (LOSS) FROM OPERATIONS	(2,417)	(53,219)	174,062	(16,461)
Interest income	4,999	1,827	9,324	8,737
Interest expense	(4,679)	(3,870)	(12,344)	(11,491)
Other income (expense), net	193	9,102	(3,908)	10,439
INCOME (LOSS) BEFORE INCOME TAXES	(1,904)	(46,160)	167,134	(8,776)
Provision for (benefit from) income taxes	4,748	(9,666)	25,324	(2,594)
NET INCOME (LOSS)	$ (6,652)	$ (36,494)	$ 141,810	$ (6,182)
NET INCOME (LOSS) PER SHARE, BASIC (in dollars per share)	$ (0.04)	$ (0.20)	$ 0.77	$ (0.03)
NET INCOME (LOSS) PER SHARE, DILUTED (in dollars per share)	$ (0.04)	$ (0.20)	$ 0.75	$ (0.03)
Weighted average common shares outstanding, basic (in shares)	185,597	183,214	185,009	182,616
Weighted average common shares outstanding, diluted (in shares)	185,597	183,214	192,252	182,616
COMPREHENSIVE INCOME (LOSS)	$ 5,625	$ (25,316)	$ 158,127	$ 20,196
Net product revenues
REVENUES:
Total revenues	493,348	393,840	1,516,533	1,348,279
Royalty and other revenues
REVENUES:
Total revenues	$ 11,996	$ 14,902	$ 41,968	$ 48,186