BUSINESS OVERVIEW AND SIGNIFICANT ACCOUNTING POLICIES (Details) $ in Thousands	9 Months Ended
	Sep. 30, 2022 USD ($) commercial_product	Jun. 30, 2022 USD ($)	Dec. 31, 2021 USD ($)		Sep. 30, 2021 USD ($)	Jun. 30, 2021 USD ($)	Dec. 31, 2020 USD ($)
Change in Accounting Estimate [Line Items]
Number of commercial products in portfolio | commercial_product	8
Accumulated deficit	$ 788,949		$ 930,759	[1]
Decrease in stockholders’ equity	(4,568,514)	$ (4,499,737)	(4,265,670)	[1]	$ (4,261,078)	$ (4,236,500)	$ (4,100,931)
Deferred tax assets	1,455,205		1,450,161	[1]
Other assets	151,788		152,121	[1]
Other long-term liabilities	$ (92,473)		(98,361)	[1]
Revision of Prior Period, Error Correction, Adjustment
Change in Accounting Estimate [Line Items]
Accumulated deficit							5,100
Decrease in stockholders’ equity		$ 5,071	5,071			$ 5,071	$ 5,071
Accounts payable and accrued liabilities			6,700
Deferred tax assets			1,100
Other assets			400
Other long-term liabilities			$ 100

[1] (1)Certain December 31, 2021 balances have been corrected for an immaterial error identified in the third quarter of 2022. See Note 1 to these Condensed Consolidated Financial Statements for details.