REVENUE, CREDIT CONCENTRATIONS AND GEOGRAPHIC INFORMATION (Tables)

9 Months Ended

Sep. 30, 2022

Concentration Risk And Geographic Information [Abstract]

Schedule of Net Product Revenues by Product

The following table disaggregates total Net Product Revenues by product.

	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
Net product revenues by product:
VIMIZIM	$	155,470	$	136,744	$	511,735	$	466,697
NAGLAZYME	99,506		71,172		343,320		297,321
PALYNZIQ	66,206		60,729		182,734		173,702
KUVAN	57,038		67,687		173,977		217,257
VOXZOGO	48,289		144		102,321		144
BRINEURA	37,793		32,984		111,691		90,641
Total net product revenues marketed by the Company	464,302		369,460		1,425,778		1,245,762
ALDURAZYME net product revenues marketed by Sanofi	29,046		24,380		90,755		102,517
Total net product revenues	493,348		393,840		1,516,533		1,348,279
Royalty and other revenues	11,996		14,902		41,968		48,186
Total revenues	$	505,344	$	408,742	$	1,558,501	$	1,396,465

Schedule of Total Net Product Revenues Based on Patient Location

The table below disaggregates total Net Product Revenues by geographic region, which is based on patient location for Company's commercial products sold directly by the Company, except for ALDURAZYME, which is sold exclusively by Sanofi worldwide.

	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
United States	$	176,552	$	166,554	$	497,205	$	491,028
Europe	162,583		108,568		480,645		424,144
Latin America	60,791		38,958		213,246		140,911
Rest of world	64,376		55,380		234,682		189,679
Total net product revenues marketed by the Company	$	464,302	$	369,460	$	1,425,778	$	1,245,762
ALDURAZYME net product revenues marketed by Sanofi	29,046		24,380		90,755		102,517
Total net product revenues	$	493,348	$	393,840	$	1,516,533	$	1,348,279

Schedule of Net Product Revenue Concentrations Attributed to Largest Customers

The following table illustrates the percentage of the Company’s total Net Product Revenues attributed to the Company’s largest customers for the periods presented. 

	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
Customer A	15	%	20	%	16	%	17	%
Customer B	14	%	16	%	12	%	14	%
Customer C	10	%	11	%	9	%	10	%
Total	39	%	47	%	37	%	41	%