CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income	$ 148,462	$ 30,312
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization	52,614	55,214
Non-cash interest expense	2,062	2,082
Amortization of premium on investments	3,070	1,878
Stock-based compensation	94,911	104,346
Gain on sale of nonfinancial assets, net	(108,000)	0
Deferred income taxes	3,455	1,204
Unrealized foreign exchange gain	(12,333)	(1,004)
Non-cash changes in the fair value of contingent consideration	1,338	4,488
Other	(18)	(376)
Changes in operating assets and liabilities:
Accounts receivable, net	(92,562)	17,420
Inventory	(1,431)	6,379
Other current assets	(12,001)	34,331
Other assets	9,149	321
Accounts payable and other short-term liabilities	(76,345)	(60,884)
Other long-term liabilities	(1,576)	585
Net cash provided by operating activities	10,795	196,296
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of property, plant and equipment	(55,971)	(48,106)
Maturities and sales of investments	311,598	348,941
Purchases of investments	(304,805)	(484,572)
Proceeds from sale of nonfinancial assets	110,000	0
Purchase of intangible assets	(2,739)	(6,400)
Other	0	(908)
Net cash provided by (used in) investing activities	58,083	(191,045)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from exercises of awards under equity incentive plans	29,493	27,640
Taxes paid related to net share settlement of equity awards	(44,377)	(38,731)
Payment of contingent consideration	(21,054)	0
Principal repayments of financing leases	(1,122)	(1,941)
Other	0	(381)
Net cash used in financing activities	(37,060)	(13,413)
Effect of exchange rate changes on cash	708	537
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS	32,526	(7,625)
Cash and cash equivalents:
Beginning of period	587,276	649,158
End of period	619,802	641,533
SUPPLEMENTAL CASH FLOW DISCLOSURES:
Cash paid for income taxes	11,821	10,159
Cash paid for interest	5,137	5,195
SUPPLEMENTAL CASH FLOW DISCLOSURES FOR NON-CASH INVESTING AND FINANCING ACTIVITIES:
Increase (decrease) in accounts payable and accrued liabilities related to fixed assets	1,012	(9,393)
Increase in accounts payable and accrued liabilities related to intangible assets	$ 6,563	$ 1,397