CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
REVENUES:
Total revenues	$ 533,798	$ 501,693	$ 1,053,157	$ 987,723
OPERATING EXPENSES:
Cost of sales	123,126	127,062	240,091	247,228
Research and development	158,190	161,107	319,026	309,832
Selling, general and administrative	196,835	184,161	391,454	358,479
Intangible asset amortization and contingent consideration	16,495	17,691	34,107	35,426
Gain on sale of nonfinancial assets, net	0	0	(108,000)	0
Total operating expenses	494,646	490,021	876,678	950,965
INCOME FROM OPERATIONS	39,152	11,672	176,479	36,758
Interest income	2,505	4,471	4,325	6,910
Interest expense	(3,859)	(3,817)	(7,665)	(7,621)
Other income (expense), net	(2,947)	1,830	(4,101)	1,337
INCOME BEFORE INCOME TAXES	34,851	14,156	169,038	37,384
Provision for income taxes	7,187	1,215	20,576	7,072
NET INCOME	$ 27,664	$ 12,941	$ 148,462	$ 30,312
NET INCOME PER SHARE, BASIC (in dollars per share)	$ 0.15	$ 0.07	$ 0.80	$ 0.17
NET INCOME PER SHARE, DILUTED (in dollars per share)	$ 0.15	$ 0.07	$ 0.79	$ 0.16
Weighted average common shares outstanding, basic (in shares)	185,254	182,844	184,710	182,311
Weighted average common shares outstanding, diluted (in shares)	187,448	185,427	191,096	185,089
COMPREHENSIVE INCOME	$ 47,013	$ 6,998	$ 152,502	$ 45,512
Net product revenues
REVENUES:
Total revenues	517,660	486,670	1,023,185	954,439
Royalty and other revenues
REVENUES:
Total revenues	$ 16,138	$ 15,023	$ 29,972	$ 33,284