CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income	$ 120,798	$ 17,371
Adjustments to reconcile net income to net cash (used in) provided by operating activities:
Depreciation and amortization	27,343	27,983
Non-cash interest expense	1,033	1,043
Amortization of premium on investments	1,652	673
Stock-based compensation	47,833	49,503
Gain on sale of nonfinancial assets, net	(108,000)	0
Deferred income taxes	4,800	3,335
Unrealized foreign exchange (gain) loss	(6,887)	3,950
Non-cash changes in the fair value of contingent consideration	1,989	2,255
Other	700	(871)
Changes in operating assets and liabilities:
Accounts receivable, net	(54,813)	40,294
Inventory	1,125	(6,425)
Other current assets	(8,011)	42,784
Other assets	1,440	1,617
Accounts payable and accrued liabilities	(78,143)	(72,304)
Other long-term liabilities	1,710	2,304
Net cash (used in) provided by operating activities	(45,431)	113,512
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of property, plant and equipment	(28,817)	(25,507)
Maturities and sales of investments	155,818	194,637
Purchases of available-for-sale securities	(147,361)	(237,171)
Proceeds from sale of nonfinancial assets	110,000	0
Purchase of intangible assets	(1,858)	(2,747)
Net cash provided by (used in) investing activities	87,782	(70,788)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from exercises of awards under equity incentive plans	8,235	5,817
Taxes paid related to net share settlement of equity awards	(32,949)	(29,097)
Principal repayments of financing leases	(566)	(1,084)
Net cash used in financing activities	(25,280)	(24,364)
Effect of exchange rate changes on cash	1,093	(205)
NET INCREASE IN CASH AND CASH EQUIVALENTS	18,164	18,155
Cash and cash equivalents:
Beginning of period	587,276	649,158
End of period	605,440	667,313
SUPPLEMENTAL CASH FLOW DISCLOSURES:
Cash paid for income taxes	1,316	2,998
Cash paid for interest	1,422	1,465
SUPPLEMENTAL CASH FLOW DISCLOSURES FOR NON-CASH INVESTING AND FINANCING ACTIVITIES:
Decrease in accounts payable and accrued liabilities related to fixed assets	(2,481)	(12,795)
Increase (decrease) in accounts payable and accrued liabilities related to intangible assets	$ (637)	$ 1,298