CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
REVENUES:
Total revenues	$ 519,359	$ 486,030
OPERATING EXPENSES:
Cost of sales	116,965	120,166
Research and development	160,836	148,725
Selling, general and administrative	194,619	174,318
Intangible asset amortization and contingent consideration	17,612	17,735
Gain on sale of nonfinancial assets, net	(108,000)	0
Total operating expenses	382,032	460,944
INCOME FROM OPERATIONS	137,327	25,086
Interest income	1,820	2,439
Interest expense	(3,806)	(3,804)
Other expense, net	(1,154)	(493)
INCOME BEFORE INCOME TAXES	134,187	23,228
Provision for income taxes	13,389	5,857
NET INCOME	$ 120,798	$ 17,371
NET INCOME PER SHARE, BASIC (in dollars per share)	$ 0.66	$ 0.10
NET INCOME PER SHARE, DILUTED (in dollars per share)	$ 0.63	$ 0.09
Weighted average common shares outstanding, basic (in shares)	183,990	181,772
Weighted average common shares outstanding, diluted (in shares)	194,886	184,365
COMPREHENSIVE INCOME	$ 105,489	$ 38,514
Net product revenues
REVENUES:
Total revenues	505,525	467,769
Royalty and other revenues
REVENUES:
Total revenues	$ 13,834	$ 18,261