Business acquisition contingent consideration potential cash payments upon achievement of sales milestone.

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- Definition

Collaborative Arrangement, Minority Equity Investment in License

+ References

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- Definition

Contingent payments upon achievement of certain development and regulatory activities and commercial sales and licensing milestones.

+ References

No definition available.

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- Definition

Royalty rate lower limit.

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Royalty rate upper limit.

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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- Definition

The cash outflow associated with the acquisition of business during the period. The cash portion only of the acquisition price.

+ References

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- Definition

Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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- Definition

Percentage of the Variable Interest Entity's (VIE) voting interest owned by (or beneficial interest in) the reporting entity (directly or indirectly).

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LICENSE AND COLLABORATION AGREEMENTS - Additional Information (Detail) $ in Thousands, € in Millions	1 Months Ended	12 Months Ended
	Oct. 31, 2019 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2021 EUR (€)	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Dec. 31, 2021 EUR (€)	Mar. 31, 2019
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue		$ 1,846,275		$ 1,860,455	$ 1,704,048
Contingent payments upon achievement of certain development and regulatory activities and commercial sales and licensing milestones		788,500
Firdapse \| Disposal Group, Disposed of by Sale, Not Discontinued Operations
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalties on net product sales							7.00%
Royalties on net product sales							10.00%
Merck Serono
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contingent payments upon achievement of certain development and regulatory activities and commercial sales and licensing milestones		68,100
Exclusive Licensing Agreement For Tralesinidase Alfa
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue	$ 3,000
Investment in equity		$ 12,600
Exclusive Licensing Agreement For Tralesinidase Alfa \| Variable Interest Entity, Not Primary Beneficiary
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Minority equity ownership	15.00%
A&R Kuvan Agreement \| Merck Serono \| Maximum
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Business acquisition contingent consideration potential cash payments upon achievement of sales milestone \| €						€ 60.0
Pegvaliase Agreement \| Merck Serono
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Business acquisition, cash paid \| €			€ 125.0