CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
CASH FLOWS FROM OPERATING ACTIVITIES:
Net Income (Loss)	$ (64,080)	$ 859,100	$ (23,848)
Adjustments to reconcile net income (loss) to net cash used in operating activities:
Depreciation and amortization	108,039	105,172	105,300
Non-cash interest expense	4,146	16,511	13,960
Amortization of premium on investments (accretion of discount)	5,155	567	(2,000)
Stock-based compensation expense	197,263	189,711	159,865
Gain on sale of nonfinancial assets	0	(59,495)	(25,000)
Inventory reserves, net of stock-based compensation	0	75,609	0
Deferred income taxes	(15,608)	(888,907)	(82,760)
Unrealized foreign exchange loss (gain)	(1,810)	8,011	1,025
Non-cash changes in the fair value of contingent consideration	8,026	4,500	5,205
Other	(2,629)	(997)	(2,393)
Changes in operating assets and liabilities:
Accounts receivable, net	65,574	(59,035)	(37,852)
Inventory	(35,060)	(61,151)	(107,554)
Other current assets	29,760	18,312	(27,008)
Other assets	(6,593)	(28,647)	(8,895)
Accounts payable and accrued liabilities	15,689	(87,025)	77,089
Other long-term liabilities	(3,336)	(6,871)	3,128
Net cash provided by operating activities	304,536	85,365	48,262
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of property, plant and equipment	(95,578)	(114,312)	(145,026)
Maturities and sales of investments	691,049	555,834	740,211
Purchase of available-for-sale debt securities	(937,143)	(529,663)	(632,023)
Proceeds from sale of nonfinancial assets	0	67,159	25,000
Purchase of intangible assets	(23,647)	(23,207)	(18,380)
Investment in convertible note	0	(8,709)	0
Other	(994)	(723)	(808)
Net cash used in investing activities	(366,313)	(53,621)	(31,026)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from exercises of awards under equity incentive plans	49,194	71,913	31,611
Taxes paid related to net share settlement of equity awards	(45,805)	(44,638)	(42,680)
Repurchase of common stock	0	(50,000)	0
Proceeds from convertible senior subordinated note offering, net	0	585,752	0
Repayments of convertible debt	0	(374,991)	0
Payment of contingent consideration	0	0	(58,518)
Principal repayments of financing leases	(3,039)	(6,918)	(5,087)
Other	(398)	0	0
Net cash provided by (used in) financing activities	(48)	181,118	(74,674)
Effect of exchange rate changes on cash	(57)	(1,150)	902
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS	(61,882)	211,712	(56,536)
Cash and cash equivalents:
Beginning of period	649,158	437,446	493,982
End of period	587,276	649,158	437,446
SUPPLEMENTAL CASH FLOW DISCLOSURES:
Cash paid for interest, net of interest capitalized into fixed assets	10,395	12,178	8,552
Cash paid for income taxes	18,153	8,977	9,726
SUPPLEMENTAL CASH FLOW DISCLOSURES FOR NON-CASH INVESTING AND FINANCING ACTIVITIES:
Increase (decrease) in accounts payable and accrued liabilities related to fixed assets	(4,749)	(5,184)	7,589
Increase (decrease) in accounts payable and accrued liabilities related to intangible assets	$ 9,428	$ (292)	$ 4,247