BUSINESS OVERVIEW AND SIGNIFICANT ACCOUNTING POLICIES - Additional Information (Detail)	12 Months Ended
Dec. 31, 2021 Segment tranche commercial_product
Significant Accounting Policies [Line Items]
Number of commercial products in portfolio \| commercial_product	7
Number of tranches in offering period \| tranche	4
Span of offering period	24 months
Number of reportable segment	1
Number of operating segments	1
Aldurazyme \| Minimum
Significant Accounting Policies [Line Items]
Payment received as percentage of net product sales	39.50%
Aldurazyme \| Maximum
Significant Accounting Policies [Line Items]
Payment received as percentage of net product sales	50.00%

Number of operating segments. An operating segment is a component of an enterprise: (a) that engages in business activities from which it may earn revenues and incur expenses (including revenues and expenses relating to transactions with other components of the same enterprise), (b) whose operating results are regularly reviewed by the enterprise's chief operating decision maker to make decisions about resources to be allocated to the segment and assess its performance, and (c) for which discrete financial information is available. An operating segment may engage in business activities for which it has yet to earn revenues, for example, start-up operations may be operating segments before earning revenues.

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 18
-URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e8672-108599

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Data Type:	xbrli:integerItemType
Balance Type:	na
Period Type:	duration