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REVENUE, CREDIT CONCENTRATIONS AND GEOGRAPHIC INFORMATION (Tables)
 12 Months Ended
Dec. 31, 2021
Risks and Uncertainties [Abstract]  
Disaggregates of Total Net Product Revenues from External Customers by Product
The following table presents Total Revenues and disaggregates Net Product Revenues by product.
Years Ended December 31,
202120202019
Net product revenues by product:
Vimizim$623,145 $544,257 $544,345 
Naglazyme380,449 391,298 374,334 
Kuvan285,776 457,736 463,353 
Palynziq237,474 170,983 86,857 
Brineura128,034 110,192 71,997 
Voxzogo5,855 — — 
Firdapse— 1,288 22,348 
Total net product revenues marketed by the Company1,660,733 1,675,754 1,563,234 
Aldurazyme net product revenues marketed by Sanofi122,765 130,107 97,809 
Total net product revenues1,783,498 1,805,861 1,661,043 
Royalty and other revenues62,777 54,594 43,005 
Total revenues$1,846,275 $1,860,455 $1,704,048 
Disaggregates of Total Net Product Revenues Based on Patient Location The table below disaggregates total Net Product Revenues by geographic region, which is based on patient location for Company's commercial products sold directly by the Company, except for Aldurazyme, which is sold exclusively by Sanofi worldwide.
Years Ended December 31,
202120202019
United States$657,700 $756,863 $669,171 
Europe558,952 498,725 485,596 
Latin America191,151 205,862 218,792 
Rest of world252,930 214,304 189,675 
Total net product revenues marketed by the Company
1,660,733 1,675,754 1,563,234 
Aldurazyme net product revenues marketed by Sanofi
122,765 130,107 97,809 
Total net product revenues$1,783,498 $1,805,861 $1,661,043 
Total Net Product Revenue Concentrations Attributed to Largest Customers
The following table illustrates the percentage of the Company’s total Net Product Revenues attributed to the Company’s largest customers for the periods presented.
Years Ended December 31,
202120202019
Customer A18 %16 %17 %
Customer B14 %15 %13 %
Customer C10 %12 %11 %
Total42 %43 %41 %
Summary of Non-Monetary Long-Lived Assets by Geographic Region Long-lived assets, which consist of net property, plant and equipment and ROU assets are summarized by geographic region in the following table.
December 31,
20212020
Long-lived assets by geography:
United States$763,847 $771,286 
Ireland304,748 300,555 
Rest of world13,284 17,739 
Total long-lived assets$1,081,879 $1,089,580