CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 587,276	$ 649,158
Short-term investments	426,599	416,228
Accounts receivable, net	373,399	448,351
Inventory	776,669	698,548
Other current assets	110,442	129,934
Total current assets	2,274,385	2,342,219
Noncurrent assets:
Long-term investments	507,793	285,473
Property, plant and equipment, net	1,035,461	1,032,471
Intangible assets, net	388,652	417,271
Goodwill	196,199	196,199
Deferred tax assets	1,449,075	1,432,150
Other assets	151,760	142,237
Total assets	6,003,325	5,848,020
Current liabilities:
Accounts payable and accrued liabilities	491,590	492,548
Short-term contingent consideration	48,232	0
Total current liabilities	539,822	492,548
Noncurrent liabilities:
Long-term convertible debt, net	1,079,077	1,075,145
Long-term contingent consideration	15,167	60,130
Other long-term liabilities	98,519	114,195
Total liabilities	1,732,585	1,742,018
Stockholders’ equity:
Common stock, $0.001 par value: 500,000,000 shares authorized;    183,912,514 and 181,740,999 shares issued and outstanding, respectively	184	182
Additional paid-in capital	5,191,502	4,993,407
Company common stock held by Nonqualified Deferred Compensation Plan (the NQDC)	(9,689)	(9,839)
Accumulated other comprehensive income (loss)	14,432	(16,139)
Accumulated deficit	(925,689)	(861,609)
Total stockholders’ equity	4,270,740	4,106,002
Total liabilities and stockholders’ equity	$ 6,003,325	$ 5,848,020