PROPERTY, PLANT AND EQUIPMENT

6 Months Ended

Jun. 30, 2020

Property, Plant and Equipment [Abstract]

PROPERTY, PLANT AND EQUIPMENT

(7) PROPERTY, PLANT AND EQUIPMENT

Property, plant and equipment, net consisted of the following: 

	June 30, 2020		December 31, 2019
Building and improvements	$	729,003	$	725,906
Manufacturing and laboratory equipment	388,720		366,951
Computer hardware and software	182,448		167,554
Land	90,418		90,418
Leasehold improvements	52,422		51,324
Furniture and equipment	38,144		38,569
Land improvements	7,349		7,349
Construction-in-progress	114,246		111,897
	1,602,750		1,559,968
Accumulated depreciation	(591,833)		(549,100)
Total property, plant and equipment, net	$	1,010,917	$	1,010,868

The construction-in-progress balance primarily included costs related to significant in-progress projects at the Company's facilities in Marin County, California, and Shanbally, Ireland.

	Three Months Ended June 30,				Six Months Ended June 30,
	2020		2019		2020		2019
Depreciation expense	$	22,042	$	21,529	$	43,562	$	42,968
Depreciation capitalized into inventory	$	11,934	$	8,570	$	23,170	$	15,087