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PROPERTY, PLANT AND EQUIPMENT
 12 Months Ended
Dec. 31, 2019
Property, Plant and Equipment [Abstract]  
PROPERTY, PLANT AND EQUIPMENT PROPERTY, PLANT AND EQUIPMENT
Property, Plant and Equipment, Net, consisted of the following:
December 31,
20192018
Building and improvements$725,906  $694,447  
Manufacturing and laboratory equipment366,951  345,947  
Computer hardware and software167,554  157,787  
Leasehold improvements51,324  41,188  
Furniture and equipment38,569  33,234  
Land improvements7,349  6,551  
Land90,418  77,993  
Construction-in-progress111,897  64,170  
1,559,968  1,421,317  
Accumulated depreciation(549,100) (472,635) 
Total property, plant and equipment, net$1,010,868  $948,682  
The construction-in-process balance primarily includes costs related to the Company’s significant in-process projects at its facilities in Marin County, California, and in Shanbally, Cork, Ireland.
Depreciation for the years ended December 31, 2019, 2018 and 2017 was $89.3 million, $90.4 million and $75.8 million, respectively, of which $37.5 million, $25.2 million and $24.1 million was capitalized into inventory, respectively.