CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2019		Sep. 30, 2018
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (38,872)		$ (73,561)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	79,510		70,955
Non-cash interest expense	9,395		26,099
(Accretion of discount) Amortization of premium on investments	(1,897)		769
Stock-based compensation	121,763		112,261
Gain on sale of intangible assets	(15,000)		(20,000)
Deferred income taxes	(59,780)		(32,735)
Unrealized foreign exchange (gain) loss	784		(11,997)
Non-cash changes in the fair value of contingent consideration	5,646		12,836
Other	(18)		(459)
Changes in operating assets and liabilities:
Accounts receivable, net	(61,803)		(95,884)
Inventory	(52,571)		(10,232)
Other current assets	(13,259)		4,276
Other assets	(7,112)		(3,148)
Accounts payable and accrued liabilities	21,747		(12,090)
Other long-term liabilities	2,386		3,744
Net cash used in operating activities	(9,081)		(29,166)
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of property, plant and equipment	(94,241)		(102,541)
Maturities and sales of investments	635,678		857,063
Purchases of available-for-sale securities	(528,497)		(439,198)
Proceeds from sale of intangible assets	15,000		20,000
Purchase of intangible assets	(8,323)		0
Other	(1,747)		(10)
Net cash provided by investing activities	17,870		335,314
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from exercises of awards under equity incentive plans	21,768		55,643
Taxes paid related to net share settlement of equity awards	(40,951)		(34,180)
Payment of contingent acquisition consideration	(57,508)		(43,108)
Other	(2,025)		0
Net cash used in financing activities	(78,716)		(21,645)
Effect of exchange rate changes on cash	(835)		(347)
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS	(70,762)		284,156
Cash and cash equivalents:
Beginning of period	493,982	[1]	598,028
End of period	423,220		882,184
SUPPLEMENTAL CASH FLOW DISCLOSURES:
Cash paid for income taxes	6,088		15,791
Cash paid for interest	5,777		7,521
SUPPLEMENTAL CASH FLOW DISCLOSURES FOR NON-CASH INVESTING AND FINANCING ACTIVITIES:
Decrease in accounts payable and accrued liabilities related to fixed assets	$ (5,801)		$ (7,678)

[1] December 31, 2018 balances were derived from the audited Consolidated Financial Statements included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2018, filed with the SEC on February 28, 2019.