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Fair Value Measurements - Liabilities Measured at Fair Value on Recurring Basis Using Level 3 Inputs (Detail) - Contingent Payment
$ in Thousands
9 Months Ended
Sep. 30, 2019
USD ($)
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]  
Contingent consideration at December 31, 2018 $ 132,834
Changes in fair value of other contingent consideration 19,916
Milestone payments to Ares Trading S.A. (Merck Serono) (83,472)
Milestone payments to former LEAD Therapeutics, Inc. shareholders (5,987)
Realized gain on settlement of contingent consideration (1,928)
Foreign exchange remeasurement of Euro denominated contingent consideration (2,433)
Contingent consideration at September 30, 2019 $ 58,930