PROPERTY, PLANT AND EQUIPMENT

9 Months Ended

Sep. 30, 2019

Property, Plant and Equipment [Abstract]

PROPERTY, PLANT AND EQUIPMENT

(7) PROPERTY, PLANT AND EQUIPMENT

Property, plant and equipment, net consisted of the following: 

	September 30, 2019			December 31, 2018
Building and improvements	$	709,990		$	694,447
Manufacturing and laboratory equipment	365,348			345,947
Computer hardware and software	165,235			157,787
Leasehold improvements	52,379			41,188
Furniture and equipment	37,603			33,234
Land improvements	7,239			6,551
Land	83,094			77,993
Construction-in-progress	84,021			64,170
	1,504,909			1,421,317
Accumulated depreciation	(535,609		)	(472,635		)
Total property, plant and equipment, net	$	969,300		$	948,682

The construction-in-progress balance primarily included costs related to significant in-process projects at the Company's facilities in Marin County, California, and Shanbally, Ireland.

Depreciation expense for the three and nine months ended September 30, 2019 was $24.2 million and $67.2 million, respectively, of which $9.8 million and $24.9 million, respectively, was capitalized into inventory. Depreciation expense for the three and nine months ended September 30, 2018 was $26.6 million and $66.7 million, respectively, of which $8.1 million and $18.6 million, respectively, was capitalized into inventory.