Share based compensation arrangement by share based payment award fair value assumptions expected forfeiture rate.

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- Definition

Share based compensation arrangement by share based payment award number of equity incentive plans.

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No definition available.

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Share based compensation arrangement by share based payment award options unvested and expected to vest outstanding aggregate intrinsic value.

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- Definition

Unrecognized cost of unvested share-based compensation awards.

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Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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- Definition

Period which an employee's right to exercise an award is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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- Definition

The number of equity-based payment instruments, excluding stock (or unit) options, that were forfeited during the reporting period.

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- Definition

The number of grants made during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

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- Definition

The number of non-vested equity-based payment instruments, excluding stock (or unit) options, that validly exist and are outstanding as of the balance sheet date.

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- Definition

The weighted average fair value of nonvested awards on equity-based plans excluding option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, revenue or profit achievement stock award plan) for which the employer is contingently obligated to issue equity instruments or transfer assets to an employee who has not yet satisfied service or performance criteria necessary to gain title to proceeds from the sale of the award or underlying shares or units.

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- Definition

The number of equity-based payment instruments, excluding stock (or unit) options, that vested during the reporting period.

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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No definition available.

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- Definition

Number of additional shares authorized for issuance under an established share-based compensation plan.

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No definition available.

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- Definition

The maximum number of shares (or other type of equity) originally approved (usually by shareholders and board of directors), net of any subsequent amendments and adjustments, for awards under the equity-based compensation plan. As stock or unit options and equity instruments other than options are awarded to participants, the shares or units remain authorized and become reserved for issuance under outstanding awards (not necessarily vested).

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- Definition

The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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- Definition

The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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- Definition

Gross number of share options (or share units) granted during the period.

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No definition available.

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- Definition

The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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- Definition

Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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Amount by which current fair value of underlying stock exceeds exercise price of fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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- Definition

Number of share instruments newly issued under a share-based compensation plan.

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- Definition

Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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No definition available.

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- Definition

Intrinsic value of equity-based compensation awards outstanding. Excludes stock and unit options.

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No definition available.

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Amount of difference between fair value of the underlying shares reserved for issuance and exercise price of vested portions of options outstanding and currently exercisable.

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Number of options vested.

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Stock-Based Compensation - Additional Information (Detail)					3 Months Ended		9 Months Ended		12 Months Ended
	Jun. 28, 2018 shares	Jul. 31, 2017 $ / shares shares	May 31, 2017 $ / shares shares	May 02, 2017 shares	Sep. 30, 2018 USD ($) $ / shares shares	Sep. 30, 2017	Sep. 30, 2018 USD ($) Plan $ / shares shares	Sep. 30, 2017	Dec. 31, 2017 USD ($) $ / shares shares
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of equity incentive plans \| Plan							2
Total Shares Outstanding					114,641		114,641		81,482
Number of Shares, Granted							58,994
Weighted average exercise price per share \| $ / shares							$ 2.96
Number of shares remaining forfeited							25,835
Unrecognized share-based compensation expense, weighted-average recognition period							2 years 4 months 24 days
Minimum [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Estimated forfeitures rate					0.00%	0.00%	0.00%	0.00%
Maximum [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Estimated forfeitures rate					8.00%	8.00%	8.00%	8.00%
Stock Options [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Intrinsic value of options outstanding \| $					$ 0		$ 0		$ 0
Intrinsic value of options exercisable \| $					0		0		0
Intrinsic value of options vested and unvested expected to vest \| $					0		0		$ 0
RSUs [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Intrinsic value shares, RSUs outstanding \| $					1,000		1,000
Intrinsic value amount, RSUs unvested and vested expected to vest \| $					$ 1,000		$ 1,000
RSUs outstanding					360		360		12,026
Issuance of restricted stock units							0
Weighted-average estimated fair value of options granted \| $ / shares					$ 415.80		$ 415.80		$ 56.10
Total RSUs forfeited							5,833
Stock Options and RSUs [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Unrecognized share-based compensation expense, stock options \| $					$ 900,474		$ 900,474
2013 Equity Incentive Plan [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total stock options and RSUs authorized					59,511		59,511
2013 Equity Incentive Plan [Member] \| Performance Stock Options [Member}
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Weighted average exercise price per share \| $ / shares		$ 41.70	$ 45.00
Weighted-average estimated fair value of options granted \| $ / shares		$ 24.90	$ 29.70
2013 Equity Incentive Plan [Member] \| Performance Stock Options [Member} \| Employees and Executive Officers [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock, shares authorized				18,333
Number of shares remaining forfeited							20,750
Number of shares vested							0
2013 Equity Incentive Plan [Member] \| Performance Stock Options [Member} \| Employees [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Shares, Granted		2,500
Number of shares remaining forfeited									83
2013 Equity Incentive Plan [Member] \| Performance Stock Options [Member} \| Chief Executive Officer [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Shares, Granted			6,666
2013 Equity Incentive Plan [Member] \| Performance Stock Options [Member} \| Chief Financial Officer [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Shares, Granted			3,333
2013 Equity Incentive Plan [Member] \| Performance Stock Options [Member} \| Chief Scientific Officer [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Shares, Granted			2,500
2013 Equity Incentive Plan [Member] \| Performance Stock Options [Member} \| Senior Medical Director [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Shares, Granted			2,500
2013 Equity Incentive Plan [Member] \| Time-Based RSUs [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Weighted-average estimated fair value of options granted \| $ / shares			$ 45.00
Vesting period							1 year
2013 Equity Incentive Plan [Member] \| Time-Based RSUs [Member] \| Chief Executive Officer [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Issuance of restricted stock units			1,666
2013 Equity Incentive Plan [Member] \| Time-Based RSUs [Member] \| Chief Financial Officer [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Issuance of restricted stock units			833
2013 Equity Incentive Plan [Member] \| Time-Based RSUs [Member] \| Chief Scientific Officer [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Issuance of restricted stock units				833
2013 Equity Incentive Plan [Member] \| Time-Based RSUs [Member] \| Senior Medical Director [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Issuance of restricted stock units				833
2013 Equity Incentive Plan [Member] \| Time-Based RSUs [Member] \| Executive Officer [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock, shares authorized				5,833
2013 Equity Incentive Plan [Member] \| Performance RSUs [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Weighted-average estimated fair value of options granted \| $ / shares			$ 45.00
2013 Equity Incentive Plan [Member] \| Performance RSUs [Member] \| Chief Executive Officer [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Issuance of restricted stock units			833
2013 Equity Incentive Plan [Member] \| Performance RSUs [Member] \| Chief Financial Officer [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Issuance of restricted stock units			833
2013 Equity Incentive Plan [Member] \| Performance RSUs [Member] \| Chief Scientific Officer [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Issuance of restricted stock units				833
2013 Equity Incentive Plan [Member] \| Performance RSUs [Member] \| Senior Medical Director [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Issuance of restricted stock units				833
2013 Equity Incentive Plan [Member] \| Performance RSUs [Member] \| Executive Officer [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock, shares authorized				5,833
2013 Equity Incentive Plan [Member] \| Performance RSU Granted on May 31, 2017 [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vested							0
Total RSUs forfeited							1,666
2013 Equity Incentive Plan [Member] \| Non-inducement Shares [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total stock options and RSUs authorized					264,098		264,098
Increase in total stock otions and RSUs authorized	146,666
Stock options and RSUs issued							69,449
Total Shares Outstanding					57,863		57,863
Common stock, shares authorized					194,649		194,649
2013 Equity Incentive Plan [Member] \| Inducement shares [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock options and RSUs issued							60,268
Total Shares Outstanding					59,434		59,434
Common stock, shares authorized					0		0