X0203 3 2010-10-07 0 0001130166 Cyclacel Pharmaceuticals, Inc. CYCC 0001044321 MARXE AUSTIN W & GREENHOUSE DAVID M C/O SPECIAL SITUATIONS FUNDS 527 MADISON AVENUE, SUITE 2600 NEW YORK NY 10022 0 0 1 0 Common Stock 4490882 I By Limited Partnerships Warrants 1 2010-01-19 2014-07-23 Common Stock 670623 I By Limited Partnerships Warrants 1.92 2010-10-07 2015-10-07 Common Stock 2053450 I By Limited Partnerships This is a joint filing by Austin W. Marxe (Marxe) and David M. Greenhouse (Greenhouse). They share voting and investment control over all securities owned by Special Situations Fund III QP, L.P. (QP), Special Situations Cayman Fund, L.P. (Cay), Special Situations Private Equity Fund, L.P. (PE) and Special Situations Life Sciences Fund, L.P. (LS), respectively. 2,301,131 shares of Common Stock are held by QP, 684,500 shares of Common Stock are held by CAY, 609,533 shares of Common Stock are held by PE and 895,718 shares of Common Stock are held by LS. The interest of Marxe and Greenhouse in the shares of Common Stock owned by QP, CAY, PE and LS is limited to the extent of his pecuniary interest. This is a joint filing by Austin W. Marxe (Marxe) and David M. Greenhouse (Greenhouse). They share voting and investment control over all securities owned by Special Situations Fund III QP, L.P. (QP), Special Situations Private Equity Fund, L.P. (PE) and Special Situations Life Sciences Fund, L.P. (LS), respectively. 432,660 warrants are held by QP, 108,165 warrants are held by PE and 129,798 warrants are held by LS. The interest of Marxe and Greenhouse in the shares of warrants owned by QP, CAY, PE and LS is limited to the extent of his pecuniary interest. This is a joint filing by Austin W. Marxe (Marxe) and David M. Greenhouse (Greenhouse). They share voting and investment control over all securities owned by Special Situations Fund III QP, L.P. (QP), Special Situations Cayman Fund, L.P. (CAY), Special Situations Private Equity Fund, L.P. (PE) and Special Situations Life Sciences Fund, L.P. (LS), respectively. 1,026,700 warrants are held by QP, 342,250 warrants are held by Cayman, 273,800 warrants are held by PE and 410,700 warrants are held by LS. The interest of Marxe and Greenhouse in the shares of warrants owned by QP, CAY, PE and LS is limited to the extent of his pecuniary interest. Austin W. Marxe 2010-10-13 David M. Greenhouse 2010-10-13