X0303 4 2009-12-10 0 0001130166 Cyclacel Pharmaceuticals, Inc. CYCC 0001044321 MARXE AUSTIN W & GREENHOUSE DAVID M C/O SPECIAL SITUATIONS FUNDS 527 MADISON AVENUE, SUITE 2600 NEW YORK NY 10022 0 0 1 0 Common Stock 2009-12-10 4 S 0 50000 1.0683 D 3942624 I By Limited Partnerships Common Stock 2009-12-10 4 S 0 150000 1.0752 D 3792624 I By Limited Partnerships Common Stock 2009-12-11 4 S 0 1009400 1.2876 D 2783224 I By Limited Partnerships This is a joint filing by Austin W. Marxe (Marxe) and David M. Greenhouse (Greenhouse). They share voting and investment control over all securities owned by Special Situations Fund III QP, L.P. (QP), Special Situations Private Equity Fund, L.P. (PE) and Special Situations Life Sciences Fund, L.P. (LS), respectively. 1,795,179 shares of Common Stock are held by QP, 448,794 shares of Common Stock are held by PE and 539,251 shares of Common Stock are held by LS. The interest of Marxe and Greenhouse in the shares of Common Stock owned by QP, PE and LS is limited to the extent of his pecuniary interest. Austin W. Marxe 2009-12-14 David M. Greenhouse 2009-12-14