X0303 4 2009-10-07 0 0000921114 TARGETED GENETICS CORP /WA/ TGEN 0001044321 MARXE AUSTIN W & GREENHOUSE DAVID M C/O SPECIAL SITUATIONS FUNDS 527 MADISON AVENUE, SUITE 2600 NEW YORK NY 10022 0 0 1 0 Common Stock 2009-10-07 4 S 0 200000 0.3048 D 1995481 I By Limited Partnerships Common Stock 2009-10-08 4 S 0 1120481 0.2647 D 875000 I By Limited Partnerships This is a joint filing by Austin W. Marxe (Marxe) and David M. Greenhouse (Greenhouse). They share voting and investment control over all securities owned by Special Situations Fund III QP, L.P (SSFQP) and Special Situations Life Sciences Fund, L.P. (LS), respectively. 659,288 shares of Common Stock are owned by SSFQP and 215,712 shares of Common Stock are owned by LS. The interest of Marxe and Greenhouse in the shares of Common Stock owned by SSFQP and LS is limited to the extent of his pecuniary interest. Austin W. Marxe 2009-10-09 David M. Greenhouse 2009-10-09