X0202 4 2007-03-05 0 0000891504 TAPESTRY PHARMACEUTICALS, INC TPPH 0001044321 MARXE AUSTIN W & GREENHOUSE DAVID M C/O SPECIAL SITUATIONS FUNDS 527 MADISON AVENUE, SUITE 2600 NEW YORK NY 10022 0 0 1 0 Common Stock 2007-03-05 4 P 0 29362 1.6118 A 4889345 I By Limited Partnerships Common Stock 2007-03-06 4 P 0 2500 1.6604 A 4891845 I By Limited Partnerships This is a joint filing by Austin W. Marxe (Marxe) and David M. Greenhouse (Greenhouse). They share voting and investment control over all securities owned by Special Situations Fund III QP, L.P (SSFQP), Special Situations Cayman Fund, L.P. (Cayman), Special Situations Private Equity Fund, LP (PE) and Special Situations Life Sciences Fund, L.P. (LS), respectively. 1,218,893 shares of Common Stock and 1,200,000 Wts owned by SSFQP, 355,510 shares of Common Stock and 350,000 Wts are owned by Cayman, 507,872 shares of common stock and 500,000 Wts are owned by PE and 409,570 shares of Common Stock and 350,000 Wts are owned by LS. The interest of Marxe and Greenhouse in the shares of Common Stock and Warrants owned by SSFQP, Cayman, PE and LS is limited to the extent of his pecuniary interest. Austin W. Marxe 2007-03-07 David M. Greenhouse 2007-03-07