X0202 4 2006-09-18 0 0001011835 MEDIVATION, INC. MDV 0001044321 MARXE AUSTIN W & GREENHOUSE DAVID M C/O SPECIAL SITUATIONS FUNDS 527 MADISON AVENUE, SUITE 2600 NEW YORK NY 10022 0 0 1 0 Common Stock 2006-09-18 4 S 0 9300 5.5511 D 3061793 I By Limited Partnerships Common Stock 2006-09-19 4 S 0 48500 5.7731 D 3013293 I By Limited Parterships Common Stock 2006-09-19 4 S 0 61700 5.9628 D 2951593 I By Limited Partnerships Common Stock 2006-09-20 4 S 0 17200 6.0218 D 2934393 I By Limited Partnerships This is a joint filing by Austin W. Marxe (Marxe) and David M. Greenhouse (Greenhouse). They share voting and investment control over all securities owned by Special Situations Fund III QP, L.P. (QP), Special Situations Cayman Fund, L.P. (Cayman), Special Situations Private Equity Fund, L.P. (PE) and Special Situations Life Sciences Fund, L.P. (LS), respectively. 1,070,715 shares of Common Stock are held by QP, 357,181 shares of Common Stock are held by Cayman, 1,317,822 shares of Common Stock are held by PE and 188,675 shares of Common Stock are held by LS. The interest of Marxe and Greenhouse in the shares of Common Stock owned by QP, Cayman, PE and LS is limited to the extent of his pecuniary interest. Austin W. Marxe 2006-09-21 David M. Greenhouse 2006-09-21