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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
 U6zO17xesu1uhoUpsyMlH35iYghmqbCjj9ppcvirXkEIjosiH+IzRn7WLwajLV0e
 AcbGsGxWw+23AGeq+L1NuQ==

<SEC-DOCUMENT>0001345463-05-000001.txt : 20051129
<SEC-HEADER>0001345463-05-000001.hdr.sgml : 20051129
<ACCEPTANCE-DATETIME>20051129095926
ACCESSION NUMBER:		0001345463-05-000001
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20051118
FILED AS OF DATE:		20051129
DATE AS OF CHANGE:		20051129

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Slay Joseph R
		CENTRAL INDEX KEY:			0001345463

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-13467
		FILM NUMBER:		051230027

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		(804) 698-8804

	MAIL ADDRESS:	
		STREET 1:		ONE SHOCKOE PLAZA
		CITY:			RICHMOND
		STATE:			VA
		ZIP:			23219

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			COMMONWEALTH BIOTECHNOLOGIES INC
		CENTRAL INDEX KEY:			0001042418
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				541641133
		STATE OF INCORPORATION:			VA
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		601 BIOTECH DRIVE
		CITY:			RICHMOND
		STATE:			VA
		ZIP:			23235
		BUSINESS PHONE:		8046483820

	MAIL ADDRESS:	
		STREET 1:		601 BIOTECH DRIVE
		CITY:			RICHMOND
		STATE:			VA
		ZIP:			23235
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2005-11-18</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001042418</issuerCik>
        <issuerName>COMMONWEALTH BIOTECHNOLOGIES INC</issuerName>
        <issuerTradingSymbol>CBTE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001345463</rptOwnerCik>
            <rptOwnerName>Slay Joseph R</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE SHOCKOE PLAZA</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>RICHMOND</rptOwnerCity>
            <rptOwnerState>VA</rptOwnerState>
            <rptOwnerZipCode>23219</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Options</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>4.559</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2005-11-18</value>
            </exerciseDate>
            <expirationDate>
                <value>2015-11-17</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock, without par value</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>15000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Non-qualified Options granted pursuant to Commonwealth Biotechnologies, Inc. 2002 Stock Incentive Plan.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/Bradley A. Haneberg, as Attorney-in-Fact</signatureName>
        <signatureDate>2005-11-29</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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