X0306 4 2017-09-22 0 0001042074 CymaBay Therapeutics, Inc. CBAY 0001367451 Loewy Caroline M C/O CYMABAY THERAPEUTICS, INC. 7999 GATEWAY BOULEVARD, SUITE 130 NEWARK CA 94560 1 0 0 0 Stock Option (right to buy) 7.47 2017-09-22 4 A 0 7500 0.00 A 2027-09-21 Common Stock 7500 7500 D The shares subject to the option shall vest in 12 equal monthly installments commencing on June 1, 2017, subject to the Reporting Person's continuous service to the Issuer as of each such date. The option allows for early exercise by the Reporting Person. /s/ Sujal Shah, Attorney-in-Fact 2017-09-26