X0508 4 2023-12-11 0001042074 CymaBay Therapeutics, Inc. CBAY 0001738144 Dorling Janet C/O CYMABAY THERAPEUTICS, INC. 7575 GATEWAY BLVD., SUITE 110 NEWARK CA 94560 1 0 0 0 1 Common Stock 2023-12-11 4 M 0 6000 4.63 A 6000 D Common Stock 2023-12-11 4 S 0 6000 20.0703 D 0 D Employee Stock Option (right to buy) 4.63 2023-12-11 4 M 0 6000 0 D 2031-04-04 Common Stock 6000 67000 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into on August 9, 2023. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.823 to $20.81, inclusive. The reporting person undertakes to provide to CymaBay Therapeutics, Inc., any security holder of CymaBay Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The option grant vests as to 1/36 of the underlying shares monthly from April 5, 2021. /s/ Paul Quinlan, as attorney-in-fact for Janet Dorling 2023-12-11