144 0001042021 XXXXXXXX LIVE 0001771917 Karuna Therapeutics, Inc. 001-38958 99 HIGH STREET 26TH FLOOR BOSTON MA 02110 857-449-2244 JONAS JEFFREY M Director Common Charles Schwab & Co., Inc.

3000 Schwab Way Westlake TX 76262

41429 8966155.32 37443954 07/03/2023 NASDAQ Common 07/03/2023 Employee Stock Option Exercise - see remarks Karuna Therapeutics, Inc. N 41429 07/03/2023 Broker Payment for Cashless Exercise Y The options covered by this filing, may be sold over various dates. 07/03/2023 03/28/2023 JEFFREY M JONAS