X0306 4 2017-12-21 false 0001597553 Sage Therapeutics, Inc. SAGE 0001042021 JONAS JEFFREY M C/O SAGE THERAPEUTICS, INC. 215 FIRST STREET CAMBRIDGE MA 02142 true true false false President & CEO Common Stock 2017-12-21 4 M false 110247.00 0.45 A 211473.00 D Common Stock 2017-12-21 4 S false 36989.00 155.48 D 174484.00 D Common Stock 2017-12-21 4 S false 71823.00 156.55 D 102661.00 D Common Stock 2017-12-21 4 S false 27152.00 157.48 D 75509.00 D Common Stock 2017-12-21 4 S false 33301.00 158.21 D 42208.00 D Common Stock 2017-12-21 4 S false 22334.00 159.53 D 19874.00 D Common Stock 2017-12-21 4 S false 13049.00 160.36 D 6825.00 D Common Stock 2017-12-21 4 S false 5000.00 162.08 D 1825.00 D Common Stock 2017-12-21 4 S false 599.00 162.59 D 1226.00 D Common Stock 2017-12-22 4 M false 12753.00 0.45 A 13979.00 D Common Stock 2017-12-22 4 S false 12753.00 155.00 D 1226.00 D Stock Option (Right to Buy) 0.45 2017-12-21 4 M false 110247.00 0.00 D 2023-08-12 Common Stock 110247.00 295305.00 D Stock Option (Right to Buy) 0.45 2017-12-22 4 M false 12753.00 0.00 D 2023-08-12 Common Stock 12753.00 282552.00 D The sales reported on this Form 4 were effected pursuant to a trading plan adopted pursuant to Rule 10b5-1 under the Securities Exchange Act of 1934, as amended. The stock option award was issued pursuant to the Sage Therapeutics, Inc., 2011 Stock Option and Incentive Plan. The option fully vested on August 12, 2017, subject to continued service through such date. This transaction was executed in multiple trades at prices ranging from $155.00 USD to $155.99 USD. The price reported above reflects the weighted average sale price. This transaction was executed in multiple trades at prices ranging from $156.00 USD to $156.99 USD. The price reported above reflects the weighted average sale price. This transaction was executed in multiple trades at prices ranging from $157.00 USD to $157.99 USD. The price reported above reflects the weighted average sale price. This transaction was executed in multiple trades at prices ranging from $158.00 USD to $158.99 USD. The price reported above reflects the weighted average sale price. This transaction was executed in multiple trades at prices ranging from $159.00 USD to $159.99 USD. The price reported above reflects the weighted average sale price. This transaction was executed in multiple trades at prices ranging from $160.00 USD to $160.97 USD. The price reported above reflects the weighted average sale price. This transaction was executed in multiple trades at prices ranging from $161.43 USD to $162.41 USD. The price reported above reflects the weighted average sale price. This transaction was executed in multiple trades at prices ranging from $162.44 USD to $162.68 USD. The price reported above reflects the weighted average sale price. /s/ Anne Marie Cook, as Attorney-in-Fact for Jeffrey M. Jonas 2017-12-22