X0206 3/A 2019-01-01 2019-01-02 0 0001711675 Nightstar Therapeutics plc NITE 0001041126 FELLOWS DAVID A C/O NIGHTSTAR, INC. 203 CRESCENT STREET, SUITE 303 WALTHAM MA 02453 1 1 0 0 Chief Executive Officer Ordinary Shares 456697 D Ordinary Shares 8610 D Ordinary Shares 6 D Ordinary Shares 10547 D Ordinary Shares 21094 D Ordinary Shares 28125 D Ordinary Shares 31641 D Ordinary Shares 82839 D Stock Option (Right to Buy) 14.24 2028-01-30 Ordinary Shares 220000 D The ordinary shares, nominal value GBP 0.01 per share, of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents one ordinary share of the Issuer. On January 2, 2019, a Form 3 was filed to report the equity holdings of the Reporting Person. The report provided by the Issuer's equity administrator contained errors relating to the Reporting Person's holdings which have been corrected herein. This Form 3/A amends and restates, in its entirety, the original Form 3. Represent unvested restricted share awards granted on December 17, 2014. Shares shall vest on a pro rata quarterly basis through April 1, 2019. Represent unvested restricted share awards granted on February 26, 2016. Shares shall vest on a pro rata quarterly basis through October 1, 2019. Represent unvested restricted share awards granted on July 20, 2016. Shares shall vest on a pro rata quarterly basis through October 1, 2019. Represent unvested restricted share awards granted on July 20, 2016. Shares shall vest on a pro rata quarterly basis through July 1, 2020. Represent unvested restricted share awards granted on July 20, 2016. Shares shall vest on a pro rata quarterly basis through January 1, 2021. Represent unvested restricted share awards granted on July 20, 2016. Shares shall vest on a pro rata quarterly basis through April 1, 2021. Represent unvested restricted share awards granted on August 23, 2017. Shares shall vest on a pro rata quarterly basis through July 1, 2021. 25% vested as of January 1, 2019. The remainder of the underlying shares will vest in in 36 equal monthly installments thereafter. Exhibit List: Exhibit 24.1 - Power of Attorney /s/ Bryan Yoon, Attorney-in-Fact 2019-01-09